Endocrine Abstracts

Background: Aberrant accumulation of cytoplasmic/nuclear β-catenin frequently occurs in breast cancers and breast cancer cell lines. Deregulated expression of Wnt ligands, sFRP1 and Dvl1, but no inactivating or activating mutations in Wnt signaling components have so far been reported. We have recently described an internally truncated LRP5 receptor (LRP5Δ) in 91% of hyperparathyroid tumors, and showed that LRP5Δ was strongly implicated in the aberrant accumulat...